Yes, I believe so.
Whole food vitamins or supplements are made from concentrated whole foods. The body recognizes them & knows how to digest them.
Synthetic (isolated nutritional) supplements, much like refined foods, have been robbed of all of the accessory nutrients that they naturally come with. They can create myriad problems and imbalances in your body if taken at high levels for long periods of time. Your body recognizes them more like drugs, or xenobiotics (foreign subjects) forcing them down one pathway or another.
The vitamins found within whole food supplements are highly complex structures, integrating an array of enzymes, coenzymes, antioxidants, trace elements, and activators (to name a few), that all work together to allow this vitamin complex (or team) to do its job in your body. Nutrients from within this team cannot be taken apart or isolated from the whole, and then be expected to do the same job in the body as the whole complex.
When synthetic or isolated vitamins are taken, the body looks for your naturally stored up supply to create the team it needs to be effective. This is why synthetic vitamins seem to work at first and then stop. It is because those stored up extra nutrients have been depleted from the body and the vitamin is less effective. Furthermore, you end up with a deficiency of nutrients you once had stored for reserve in your body.
To put it into perspective, let me ask you one question. Would you drive a car without a tire or breaks?
Absolutely not! You need the whole team (or complex) for a car to work effectively. Same with vitamins…